abstract：BACKGROUND:Because of the changing dietary habits of an aging population, hyperuricemia is frequently found in combination with other metabolic disorders. Longstanding elevation of the serum uric acid level can lead to the deposition of monosodium urate crystals, causing gout (arthritis, urate nephropathy, tophi). In G...

journal_title：Deutsches Arzteblatt international

authors： Tausche AK,Jansen TL,Schröder HE,Bornstein SR,Aringer M,Müller-Ladner U

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:For prospective parents at risk of transmitting a monogenic disease, polar body analysis is an option for pre-conception genetic diagnosis. In Germany, polar body analysis is currently performed in only two centers (Lübeck and Regensburg). METHODS:The authors present a clinical series of 9 couples at risk f...

journal_title：Deutsches Arzteblatt international

authors： Griesinger G,Bündgen N,Salmen D,Schwinger E,Gillessen-Kaesbach G,Diedrich K

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:Because the course of Legg-Calvé-Perthes disease (LCPD) is highly variable, its appropriate diagnostic evaluation and treatment are still debated. METHODS:The authors selectively review the literature, present their own study findings, and discuss the guidelines of the German Society for Orthopedics and Ort...

journal_title：Deutsches Arzteblatt international

authors： Nelitz M,Lippacher S,Krauspe R,Reichel H

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:As life expectancies rise and the number of persons over age 75 in the population increases, the proper treatment of elderly cardiac patients is becoming a matter of ever greater medical and political importance. METHODS:In collaboration with the German Federal Quality Assurance Office (Bundesgeschäftsstell...

journal_title：Deutsches Arzteblatt international

authors： Friedrich I,Simm A,Kötting J,Thölen F,Fischer B,Silber RE

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:In endocrine orbitopathy (EO), disfiguring proptosis and diplopia impair patients' quality of life both at home and at work. METHODS:From late 2006 to the beginning of 2008, 250 outpatients in an interdisciplinary thyroid and eye clinic filled out a questionnaire about their quality of life, occupational di...

journal_title：Deutsches Arzteblatt international

authors： Ponto KA,Pitz S,Pfeiffer N,Hommel G,Weber MM,Kahaly GJ

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Prostatic cancer (PCa) is the most common cancer in men in Germany. The goal of this review is to define the indication for hormonal treatment in patients over age 70. METHODS:A selective search of the literature up to 2008 for the terms "prostate cancer", "androgen suppression and deprivation", "hormone th...

journal_title：Deutsches Arzteblatt international

authors： Pfitzenmaier J,Altwein JE

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The epidermal growth factor receptor (EGFR) is an important target in the treatment of metastatic colorectal carcinoma (mCRC). The combination of anti-EGFR antibodies with chemotherapy has led to a higher response rate of certain kinds of tumor as well as a significant prolongation of the progression-free in...

journal_title：Deutsches Arzteblatt international

authors： Stintzing S,Heinemann V,Moosmann N,Hiddemann W,Jung A,Kirchner T

更新日期：2009-03-01 00:00:00

abstract：INTRODUCTION:Crohn's disease and ulcerative colitis are chronic inflammatory diseases resulting from an inappropriate immune response, in genetically susceptible individuals, to microbial antigens of commensal microorganisms. This inappropriate response is promoted by certain environmental factors. Both diseases manife...

journal_title：Deutsches Arzteblatt international

authors： Baumgart DC

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Epilepsy is the third most common disease affecting the brain in the elderly. Current demographic trends will lead to an increased prevalence of epilepsy in the general population. METHOD:A selective literature search revealed 102 relevant publications as of September 2008, 50 of which were original article...

journal_title：Deutsches Arzteblatt international

authors： Werhahn KJ

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Basically two types of sweating exist: thermoregulatory and emotional sweating. They are controlled by different centers: thermo regulatory sweating is regulated predominantly by the hypothalamus, emotional sweating predominantly by the limbic system. Enhanced sweating, called hyperhidrosis, can be generaliz...

journal_title：Deutsches Arzteblatt international

authors： Schlereth T,Dieterich M,Birklein F

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Gender identity disorders (GID) can appear even in early infancy with a variable degree of severity. Their prevalence in childhood and adolescence is below 1%. GID are often associated with emotional and behavioral problems as well as a high rate of psychiatric comorbidity. Their clinical course is highly ...

journal_title：Deutsches Arzteblatt international

authors： Korte A,Lehmkuhl U,Goecker D,Beier KM,Krude H,Grüters-Kieslich A

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:A confusing variety of options are available for the treatment of depressive disorders. METHOD:Selective literature review under consideration of current guidelines. RESULTS:The treatment of depression can be divided into acute, maintenance and prophylactic phases. The basic forms of treatment are pharma...

journal_title：Deutsches Arzteblatt international

authors： Bschor T,Adli M

更新日期：2008-11-01 00:00:00

abstract：INTRODUCTION:Intermittent paradoxical closure of the vocal cords can induce major attacks of dyspnea. Such attacks, called "vocal cord dysfunction" (VCD), are an important element in the differential diagnosis of intractable bronchial asthma. METHODS:Selective review of the literature. RESULTS:The etiology of VCD is ...

journal_title：Deutsches Arzteblatt international

authors： Kenn K,Hess MM

更新日期：2008-10-01 00:00:00

abstract：INTRODUCTION:Despite recent advances in their treatment, schizophrenic disorders are still among the diseases that most severely impair patients' quality of life. For this reason, centers for the early recognition of schizophrenic disorders have come into existence worldwide. In these centers, much effort is devoted to...

journal_title：Deutsches Arzteblatt international

authors： Klosterkötter J

更新日期：2008-07-01 00:00:00

abstract：INTRODUCTION:The purpose of this article is to present the results of microsurgical clipping or endovascular coil obliteration of unruptured intracranial aneurysms (UIA), in a single cerebrovascular center with regard to successful obliteration and periprocedural complications. METHODS:Data concerning patients with UI...

journal_title：Deutsches Arzteblatt international

authors： Seifert V,Gerlach R,Raabe A,Güresir E,Beck J,Szelényi A,Setzer M,Vatter H,Du Mesnil de Rochemont R,Zanella F,Sitzer M,Berkefeld J

更新日期：2008-06-01 00:00:00

abstract：INTRODUCTION:This study analyzes the prevalence and associated factors for smoking and passive smoking among young people. METHODS:The data are derived from a subsample of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), carried out by the Robert Koch Institute between May 2003 ...

journal_title：Deutsches Arzteblatt international

authors： Lampert T

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:The trauma registry of the German Society of Trauma Surgery is a multicentric prospective record of the treatment of severely injured patients. METHODS:The present study examines the effect of a quality management system on key processes and outcomes, in hospitals included in the trauma registry. The stud...

journal_title：Deutsches Arzteblatt international

authors： Ruchholtz S,Lefering R,Paffrath T,Oestern HJ,Neugebauer E,Nast-Kolb D,Pape HC,Bouillon B

更新日期：2008-03-01 00:00:00

abstract：INTRODUCTION:Data on the prevalence and regional distribution of the metabolic syndrome in Germany are lacking, in particular for primary care. METHODS:In October 2005 anthropometric measurements were taken from 35 869 consecutive patients aged 18 to 99 years, in 1511 primary care practices. Waist circumference, blood...

journal_title：Deutsches Arzteblatt international

authors： Moebus S,Hanisch J,Bramlage P,Lösch C,Hauner H,Wasem J,Jöckel KH

更新日期：2008-03-01 00:00:00

abstract：INTRODUCTION:The range of indications for vitreoretinal surgery has widened in recent years, and intraocular gas application is frequently performed as part of retinal surgery, with the aim of achieving long-acting tamponade. METHODS:Selective literature review. RESULTS:An intraocular gas bubble containing perfluorop...

journal_title：Deutsches Arzteblatt international

authors： Silvanus MT,Moldzio P,Bornfeld N,Peters J

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:The choice of type of heart valve prosthesis is determined by the patient's age since bioprostheses have a limited lifespan. This article reviews current recommendations and the literature on cardiac valve replacement. METHODS:Selective literature search in Medline/PubMed back to 1996 and review of curren...

journal_title：Deutsches Arzteblatt international

authors： Hoffmann G,Lutter G,Cremer J

更新日期：2008-02-01 00:00:00

abstract：INTRODUCTION:Magnetic resonance tomography (MRT) is the investigation of choice for diagnosing cerebral glioma, but its capacity to differentiate tumor tissue from non-specific tissue changes is limited. Positron emission tomography (PET) and single photon emission computerized tomography (SPECT) using radiolabeled ami...

journal_title：Deutsches Arzteblatt international

authors： Langen KJ,Tatsch K,Grosu AL,Jacobs AH,Weckesser M,Sabri O

更新日期：2008-01-01 00:00:00